American Association of Critical-Care Nurses (AACN) Certification Practice Test

Which of the following is a sign of hypoglycemia as noted in the acronym "TIRED"?

1. Polyuria

2. Diaphoresis

3. Polyphagia

4. Weight loss

The correct answer is: Diaphoresis

Diaphoresis, or excessive sweating, is indeed recognized as a sign of hypoglycemia and is part of the mnemonic "TIRED," which stands for Tachycardia, Irritability, Restlessness, Excessive sweating, and Dizziness. When blood sugar levels drop, the body reacts by releasing adrenaline (epinephrine), which triggers sweating—a response intended to help the body cope with low glucose levels. This physiological response is critical to understand because it highlights the body's attempt to signal that further action, such as glucose intake, is necessary to restore normal blood sugar levels. In contrast, polyuria, polyphagia, and weight loss are more commonly associated with hyperglycemia and conditions like diabetes, where the blood sugar is excessively high. Polyuria refers to increased urination, polyphagia denotes increased hunger, and weight loss can occur due to the body's inability to utilize glucose for energy, leading to the breakdown of muscle and fat for alternative fuel. Recognizing these distinctions can aid healthcare professionals in assessing and managing patients at risk for either hypo- or hyperglycemia appropriately.